hrp0084p3-937 | GH & IGF | ESPE2015

The Blood Oxidant System and Insulin Resistance in Girls with Turner Syndrome after 1 Year of GH Therapy

Pankratova Maria , Faassen Maria , Shiryaeva Tatyana , Nagaeva Elena , Peterkova Valentina , Baizhumanov Adil , Yusipovich Alexander , Cherkashin Alexander , Maksimov Georgy

Background: The effects of recombinant GH therapy on development of oxidative stress and insulin resistance in girls with Turner syndrome (TS) were observed.Objective and hypotheses: The aim of this study is to examine the longitudinal relationships of oxidative stress markers with the development of insulin resistance during GH treatment in girls with TS.Method: Ten prepubertal girls (aged 12–14 years; median 13.0 years) with...

hrp0086p1-p622 | Growth P1 | ESPE2016

Major Plasma Carotenoids Levels in Growth Hormone Deficient Children

Pankratova Maria , Yusipovich Alexander , Vorontsova Maria , Baizhumanov Adil , Cherkashin Alexander , Shiryaeva Tatiana , Solovchenko Alexei , Peterkova Valentina

Background: Carotenoids are potent antioxidants that affect many different metabolic processes. In plasma, carotenoids are transported with lipoproteins. Growth hormone deficiency (GHD) is known to induce oxidative stress and deterioration in the lipid profile, which can change the level and composition of carotenoids. Particularly interesting to measure these parameters in GHD children.Objective and hypotheses: The aim of this study is to examine the am...